Engineering PTEN-L for Cell-Mediated Delivery
نویسندگان
چکیده
منابع مشابه
Engineering PTEN-L for Cell-Mediated Delivery
The tumor suppressor PTEN is frequently inactivated in glioblastoma. PTEN-L is a long form of PTEN produced by translation from an alternate upstream start codon. Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken up by neighboring cells. This suggests that PTEN-L could be used as a therapeutic to restore PTEN ...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2018
ISSN: 2329-0501
DOI: 10.1016/j.omtm.2017.11.006